UOBScholar Hub
UOB Libraries created the UOBScholar Hub, an Institutional Repository (IR) for archiving and collecting all the research output of the UOB community. It aims to improve the visibility, usage and impact of research conducted at UOB. Materials included are: academic journal articles, conference papers and presentations, books and book chapters, ongoing research papers, reports and patents.
Submit your Publication
Please use this identifier to cite or link to this item:
https://scholarhub.balamand.edu.lb/handle/uob/1771| Title: | Complex of a new racemic thiourea substrate: spectrophotometric study and separation of atropisomers | Authors: | Salma, Yahya Zakaria, Hassan Hassan, Inas EL Bouchekara, Mohammad Nakat, Hanna El Omar, Fawaz El Allouch, Ahmad |
Affiliations: | Department of Chemistry | Keywords: | Thiourea HP-Beta-CD HPLC Atropisomeric separation Inclusion complexes |
Issue Date: | 2018 | Part of: | International journal of pharmaceutical chemistry | Volume: | 8 | Issue: | 1 | Start page: | 1 | End page: | 6 | Abstract: | The activity of a chiral molecule can vary from one atropisomer to the other. In this study, the separation of racemic-N-(2-methylphenyl), N-(2-chlorophenyl) thiourea (H2L2), a hydrophobic heavy metal trap, has been studied using reversed-phase high-performance liquid chromatography (RP-HPLC) with hydroxypropyl-beta-cyclodextrin (HP-β-CD) as a complexing additive to the racemic mixture and hexane-isopropanol as a mobile phase. The stoichiometry and the overall association constant of the complex have been determined using the continuous variation (Job's plot) method and the Scott's method respectively. |
URI: | https://scholarhub.balamand.edu.lb/handle/uob/1771 | Open URL: | Link to full text | Type: | Journal Article |
| Appears in Collections: | Department of Chemistry |
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.