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Title: Complex of a new racemic thiourea substrate: spectrophotometric study and separation of atropisomers
Authors: Salma, Yahya
Zakaria, Hassan
Hassan, Inas EL
Bouchekara, Mohammad
Nakat, Hanna El 
Omar, Fawaz El
Allouch, Ahmad
Affiliations: Department of Chemistry 
Keywords: Thiourea
Atropisomeric separation
Inclusion complexes
Issue Date: 2018
Part of: International journal of pharmaceutical chemistry
Volume: 8
Issue: 1
Start page: 1
End page: 6
The activity of a chiral molecule can vary from one atropisomer to the other. In this study, the separation of racemic-N-(2-methylphenyl), N-(2-chlorophenyl) thiourea (H2L2), a hydrophobic heavy metal trap, has been studied using reversed-phase high-performance liquid chromatography (RP-HPLC) with hydroxypropyl-beta-cyclodextrin (HP-β-CD) as a complexing additive to the racemic mixture and hexane-isopropanol as a mobile phase. The stoichiometry and the overall association constant of the complex have been determined using the continuous variation (Job's plot) method and the Scott's method respectively.
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Chemistry

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