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|Title:||Complex of a new racemic thiourea substrate : Spectrophotometric study and separation of atropisomers||Authors:||Salma, Yahya
Hassan, Inas EL
Nakat, Hanna El
Omar, Fawaz El
|Affiliations:||Department of Chemistry||Keywords:||Thiourea
|Issue Date:||2018||Part of:||International journal of pharmaceutical chemistry||Volume:||8||Issue:||1||Start page:||1||End page:||6||Abstract:||
The activity of a chiral molecule can vary from one atropisomer to the other. In this study, the separation of racemic-N-(2-methylphenyl), N-(2-chlorophenyl) thiourea (H2L2), a hydrophobic heavy metal trap, has been studied using reversed-phase high-performance liquid chromatography (RP-HPLC) with hydroxypropyl-beta-cyclodextrin (HP-β-CD) as a complexing additive to the racemic mixture and hexane-isopropanol as a mobile phase. The stoichiometry and the overall association constant of the complex have been determined using the continuous variation (Job's plot) method and the Scott's method respectively.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/1771||Open URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Department of Chemistry|
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