Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/7575
Title: Evaluating the effect of Inula viscosa and Prunus dulcis leaf extracts on gram-negative multi-drug resistant microbes
Authors: Aridi, Rola Al
Advisors: Abdou, Elias
Keywords: Antimicrobial resistance, MDROs, Inula viscosa, Prunus dulcis, MIC, MBC
Subjects: University of Balamand--Dissertations
Dissertations, Academic
Issue Date: 2024
Publisher: [Kalhat, Lebanon] : [University of Balamand], 2024
Abstract: 
Antimicrobial resistance (AMR) is a global life-threatening health concern, and it is worsening progressively with the minimal resolutions developed to prevent its further dissemination. AMR is a consequence of multiple public health malpractices, starting with the random use of antimicrobials to the weakness of antimicrobial stewardship guidelines and reinforcement. Bacteria expressing antimicrobial resistance to several drugs are referred to as multi-drug resistant organisms (MDROs). One alternative therapeutic pathway is the use of diverse plant phytochemicals which reflect promising results in treating infections and limiting bacterial
resistance. Inula viscosa and Prunus dulcis leaves were revealed to have potential antimicrobial and antiproliferation effects. In this study, the leaves of Inula viscosa and Prunus dulcis were extracted and fractionated. Their potential antimicrobial effects were evaluated by Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentrations (MBC). The MBC of Inula viscosa ethanol and ethyl acetate extracts was detected at 320µg/µl in 45 and 35 strains respectively. The MIC varied between 320 & 160 µg/µl in 57 strains for the ethanol extract and in 50 strains for the ethyl acetate extract. As for the Prunus Dulcis, the MBC of itsethanol extract varied between 80 & 320 µg/µl and the MIC varied between 40 & 160 µg/µl in 59 strains. The MBC of ethyl acetate extract ranged between 160 & 320 µg/µl whereas the MIC values were between 80 & 320 µg/µl in 54 strains. Moreover, the MIC of the dichloromethane and aqueous extracts of Prunus dulcis varied between 160 & 320 µg/µl in 52 and 46 strains respectively, whereas the MBC was detected at 320 µg/µl in 40 and 35 strains respectively.The outcomes of this study verified the efficacy of the two plants, Inula viscosa and Prunus dulcis, in combating the resistance of ESBL (Extended Spectrum Beta-Lactamases) and/or CRE (Carbapenem-Resistant Enterobacterales) bacteria strains including E. coli, K. pneumoniae, A. baumannii, P. mirabilis, P. aeruginosa, and E. cloacae.
Description: 
Includes bibliographical references (p. 60-75)
URI: https://scholarhub.balamand.edu.lb/handle/uob/7575
Rights: This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the personal and educational use exceptions must be obtained from the copyright holder
Type: Thesis
Appears in Collections:UOB Theses and Projects

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