Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/7534
Title: Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation
Authors: Muturi, Harrison T
Ghadieh, Hilda 
Asalla, Suman
Lester, Sumona G
Belew, Getachew D
Zaidi, Sobia
Abdolahipour, Raziyeh
Shrestha, Abhishek P
Portuphy, Agnes O
Stankus, Hannah L
Helal, Raghd Abu
Verhulst, Stefaan
Duarte, Sergio
Zarrinpar, Ali
van Grunsven, Leo A
Friedman, Scott L
Schwabe, Robert F
Hinds, Terry D
Kumarasamy, Sivarajan
Najjar, Sonia M
Affiliations: Faculty of Medicine 
Keywords: Hepatic fibrosis
Hepatic steatosis
Inflammation
Retinoic acid
Stellate cell proliferation
Issue Date: 2024-08-19
Publisher: Elsevier
Part of: Molecular Metabolism
Volume: 88
Abstract: 
Hepatic CEACAM1 expression declines with advanced hepatic fibrosis stage in patients with metabolic dysfunction-associated steatohepatitis (MASH). Global and hepatocyte-specific deletions of Ceacam1 impair insulin clearance to cause hepatic insulin resistance and steatosis. They also cause hepatic inflammation and fibrosis, a condition characterized by excessive collagen production from activated hepatic stellate cells (HSCs). Given the positive effect of PPARĪ³ on CEACAM1 transcription and on HSCs quiescence, the current studies investigated whether CEACAM1 loss from HSCs causes their activation.
URI: https://scholarhub.balamand.edu.lb/handle/uob/7534
DOI: 10.1016/j.molmet.2024.102010
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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