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Title: | Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation | Authors: | Muturi, Harrison T Ghadieh, Hilda Asalla, Suman Lester, Sumona G Belew, Getachew D Zaidi, Sobia Abdolahipour, Raziyeh Shrestha, Abhishek P Portuphy, Agnes O Stankus, Hannah L Helal, Raghd Abu Verhulst, Stefaan Duarte, Sergio Zarrinpar, Ali van Grunsven, Leo A Friedman, Scott L Schwabe, Robert F Hinds, Terry D Kumarasamy, Sivarajan Najjar, Sonia M |
Affiliations: | Faculty of Medicine | Keywords: | Hepatic fibrosis Hepatic steatosis Inflammation Retinoic acid Stellate cell proliferation |
Issue Date: | 2024-08-19 | Publisher: | Elsevier | Part of: | Molecular Metabolism | Volume: | 88 | Abstract: | Hepatic CEACAM1 expression declines with advanced hepatic fibrosis stage in patients with metabolic dysfunction-associated steatohepatitis (MASH). Global and hepatocyte-specific deletions of Ceacam1 impair insulin clearance to cause hepatic insulin resistance and steatosis. They also cause hepatic inflammation and fibrosis, a condition characterized by excessive collagen production from activated hepatic stellate cells (HSCs). Given the positive effect of PPARĪ³ on CEACAM1 transcription and on HSCs quiescence, the current studies investigated whether CEACAM1 loss from HSCs causes their activation. |
URI: | https://scholarhub.balamand.edu.lb/handle/uob/7534 | DOI: | 10.1016/j.molmet.2024.102010 | Open URL: | Link to full text | Type: | Journal Article |
Appears in Collections: | Faculty of Medicine |
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