Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/7492
Title: Intra-articular interventions in osteoarthritis: Navigating the landscape of hyaluronic acid, mesenchymal stem cells, and platelet-rich plasma
Authors: Soufan, Somar
Al Khoury, Joenne
Hamdan, Zahi
Rida, Mohamad Ali
Affiliations: Faculty of Medicine 
Faculty of Medicine 
Faculty of Medicine 
Keywords: Hyaluronic acid (HA)
Osteoarthritis
Viscosupplementation
Platelets
Stem cell
Issue Date: 2024-08-18
Publisher: Baishideng Publishing Group Inc.
Part of: World Journal of Orthopedics
Volume: 15
Issue: 8
Start page: 704
End page: 712
Abstract: 
Osteoarthritis (OA) poses a substantial burden on patients, leading to pain, functional decline, and reduced quality of life. While conventional treatments focus on symptom management, disease-modifying interventions are yet to be established. This review explores the efficacy of intra-articular interventions, particularly hyaluronic acid (HA), mesenchymal stem cells (MSCs), and platelet-rich plasma (PRP), in the context of OA management. HA injections, with diverse formulations like Hylan G-F20, sodium hyaluronate, and hyaluronan, present varying outcomes, necessitating a nuanced understanding of their effectiveness and timing. MSC therapy, derived from adipose tissue, umbilical cord, or bone marrow, shows promising results in clinical improvement, with adipose-derived MSCs demonstrating efficacy in maintaining benefits over 6 mo. Conversely, bone-marrow-derived MSCs show limited effectiveness, highlighting the need for source-specific considerations. PRP has emerged as a superior option for long-term pain reduction and quality of life improvement, with leukocyte-poor formulations and a critical platelet count of 10 billion demonstrating optimal results. This comprehensive analysis underscores the potential of intra-articular interventions in OA management, emphasizing the need for personalized and evidence-based approaches to enhance treatment efficacy and patient outcomes.
URI: https://scholarhub.balamand.edu.lb/handle/uob/7492
ISSN: 2218-5836
DOI: 10.5312/wjo.v15.i8.704
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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