Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/7481
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dc.contributor.authorJeradeh, Eliasen_US
dc.contributor.authorFrangie, Christianen_US
dc.contributor.authorBazzi, Sameren_US
dc.contributor.authorDaher, Jalilen_US
dc.date.accessioned2024-08-26T09:52:47Z-
dc.date.available2024-08-26T09:52:47Z-
dc.date.issued2024-08-01-
dc.identifier.issn17534259-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/7481-
dc.description.abstractCardiovascular diseases (CVDs) linked to atherosclerosis remains the leading cause of death worldwide. Atherosclerosis is primarily caused by the accumulation of oxidized forms of low density lipoprotein (LDL) in macrophages (MΦs) in the subendothelial layer of arteries leading to foam cell and fatty streak formation. Many studies suggest that LDL that is modified by myeloperoxidase (MPO) is a key player in the development of atherosclerosis. MΦs can adopt a variety of functional phenotypes that include mainly the proinflammatory M1 and the anti-inflammatory M2 MΦ phenotypes which are both implicated in the process of atherogenesis. In fact, MΦs that reside in atherosclerostic lesions were shown to express a variety of phenotypes ranging between the M1- and M2 MΦ types. Recently, we pointed out the involvement of MPO oxidized-LDL (Mox-LDL) in increasing inflammation in MΦs by reducing their secretion of IL-10. Since little is known about Mox-LDL-mediated pro-atherosclerostic responses in MΦs, our study aimed at analyzing the in vitro effects of Mox-LDL at this level through making use of the well-established model of human THP-1-derived Mφs. Our results demonstrate that Mox-LDL has no effect on apoptosis, reactive oxygen species (ROS) generation and cell death in our cell model; yet, interestingly, our results show that Mox-LDL is significantly engulfed at a higher rate in the different MΦ subtypes supporting its key role in foam cell formation during the progression of the disease as well as previous data that were generated using another primary MΦ cell model of atherosclerosis.en_US
dc.language.isoengen_US
dc.publisherSageen_US
dc.subjectAtherosclerosisen_US
dc.subjectMox-LDLen_US
dc.subjectFoam cellsen_US
dc.subjectTHP-1en_US
dc.subjectMacrophagesen_US
dc.titleThe in vitro effect of myeloperoxidase oxidized LDL on THP-1 derived macrophagesen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1177/17534259241269687-
dc.identifier.pmid39090856-
dc.identifier.scopus2-s2.0-85200236853-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85200236853-
dc.contributor.affiliationFaculty of Medicineen_US
dc.contributor.affiliationDepartment of Biologyen_US
dc.date.catalogued2024-08-26-
dc.description.statusIn Pressen_US
dc.identifier.ezproxyURLhttp://ezsecureaccess.balamand.edu.lb/login?url=https://doi.org/10.1177/1753425924126968en_US
dc.relation.ispartoftextInnate Immunityen_US
crisitem.author.parentorgFaculty of Arts and Sciences-
Appears in Collections:Department of Biology
Faculty of Medicine
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