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Title: Hydroxychloroquine and the associated risk of arrhythmias
Authors: Farhat, Hadi
Kassab, Celine J.
Tlaiss, Yehya
Gutlapalli, Sai Dheeraj
Ganipineni, Vijay Durga Pradeep
Paramsothy, Jananthan
Tedesco, Sarah
Kailayanathan, Tharunjan
Abdulaal, Razan
Otterbeck, Philip
Affiliations: Faculty of Medicine 
Faculty of Medicine 
Issue Date: 2024-01-01
Part of: Global Cardiology Science and Practice
Volume: 12
Issue: 2
Hydroxychloroquine (HCQ), which was initially used as an antimalarial drug, is now being used to treat other illnesses, especially rheumatic autoimmune disorders such as systemic lupus erythematosus, primary Sjögren's syndrome, and rheumatoid arthritis, because it is safe, effective, and cost efficient. This drug has shown high efficacy and has become the first-line treatment for many of these diseases. Although HCQ has many therapeutic effects, it has unfortunately shown some complications, especially with its long-term use. One of these side effects is arrhythmia through prolongation of the QT interval. This narrative literature review focuses on the effects of HCQ on the QT interval in patients with rheumatologic diseases who have been prescribed this drug. In particular, we will focus on the increased risk of arrhythmia when HCQ is administered with other drugs, such as azithromycin and many others, along with drug-drug interactions. In addition, we investigated the safety of this drug in pregnant women.
DOI: 10.21542/gcsp.2024.17
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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