Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/7304
Title: Glioblastoma stem cell metabolism and immunity
Authors: Hawly, Joseph
Murcar, Micaela G
Schcolnik-Cabrera, Alejandro
Issa, Mark E
Affiliations: Faculty of Medicine 
Keywords: Brain tumors
Cancer metabolism
Cancer stem cells
Elimination
Equilibrium
Escape
Immunoediting
Immunotherapy
Microglia
Natural killer cells
Resistance
Self-renewal
Surveillance
T cells
Tumorigenicity
Issue Date: 2024-03-26
Publisher: Elsevier
Part of: Cancer and Metastasis Reviews
Abstract: 
Despite enormous efforts being invested in the development of novel therapies for brain malignancies, there remains a dire need for effective treatments, particularly for pediatric glioblastomas. Their poor prognosis has been attributed to the fact that conventional therapies target tumoral cells, but not glioblastoma stem cells (GSCs). GSCs are characterized by self-renewal, tumorigenicity, poor differentiation, and resistance to therapy. These characteristics represent the fundamental tools needed to recapitulate the tumor and result in a relapse. The mechanisms by which GSCs alter metabolic cues and escape elimination by immune cells are discussed in this article, along with potential strategies to harness effector immune cells against GSCs. As cellular immunotherapy is making significant advances in a variety of cancers, leveraging this underexplored reservoir may result in significant improvements in the treatment options for brain malignancies.
URI: https://scholarhub.balamand.edu.lb/handle/uob/7304
ISSN: 01677659
DOI: 10.1007/s10555-024-10183-w
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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