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Title: Performance of sodium-glucose cotransporter 2 inhibitors in cardiovascular disease
Authors: Khater, Jacinthe
Malakouti, Sara
Khoury, Antoine El
Cortese, Bernardo
Affiliations: Faculty of Medicine 
Keywords: All spectrums of heart failure
Cardiovascular disease
Kidney disease
Sodium-glucose cotransporter 2 inhibitors
Type 2 diabetes
Issue Date: 2024-04-01
Part of: Journal of Cardiovascular Medicine
Volume: 25
Issue: 4
Start page: 247
End page: 258
The use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) as a new class of drug in treating type 2 diabetes has expanded beyond its original framework. Positive results have been achieved in reducing symptoms in patients with cardiovascular disease (CVD). The aim of this article is to present an in-depth review of the basic principles of this class of medications and how it has brought benefits to patients affected particularly by heart failure.

Following a thorough PubMed search, this review includes 62 studies published between 2015 and 2023. Keywords searched included ‘sodium-glucose cotransporter 2 inhibitors’, ‘cardiovascular disease’, ‘heart failure’, ‘chronic kidney disease’, and ‘type 2 diabetes’. The most recent and comprehensive data were used.

Positive results have been achieved in reducing symptoms in patients with CVD. SGLT2 inhibitors have also been shown to be useful in other contexts such as nonalcoholic fatty liver disease (NAFLD) by reducing liver fat accumulation, kidney benefits by improving body weight and vascular endothelium, improving eGFR, and reducing progression to end stage kidney disease (ESKD). SGLT2 inhibitors are also effective in reducing the need for heart failure hospitalizations and the risk of serious cardiac adverse events, including cardiovascular and all-cause mortality, in patients with reduced or preserved left ventricular (LV) ejection fraction and in acute or decompensated settings.

SGLT2 inhibitors have evolved into metabolic drugs because of their multisystem action and are indicated for the treatment of all spectrums of heart failure, type 2 diabetes, and chronic kidney disease.
ISSN: 15582027
DOI: 10.2459/JCM.0000000000001598
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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