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Title: CDH1 gene mutation, a challenging surgical topic: Case report and literature review
Authors: Maalouf, Hani
Saber, Toufic
Ghattas, Souad
Meguerian-Bedoyan, Zarouhie
El Rassi, Ziad
Affiliations: Faculty of Medicine 
Faculty of Medicine 
Keywords: CDH1 gene
Case report
Lobular breast carcinoma
Prophylactic total gastrectomy
Issue Date: 2024-02-21
Publisher: National Library of Medicine
Part of: International Journal of Surgery Case Reports
Volume: 116
Gastric cancer is one of the top 5 cancers worldwide. Most gastric cancers are classified as sporadic with the exception of around 3 % that are associated with specific syndromes or genes. Hereditary diffuse gastric cancer is a very rare type of gastric cancer, associated with loss of function of a tumor suppressor gene CDH1 which has a high penetrance that can reach 90 % over a lifetime.
ISSN: 2210-2612
DOI: 10.1016/j.ijscr.2024.109422
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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