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Title: Coronary artery disease patients with rs7904519 (TCF7L2) are at a persistent risk of type 2 diabetes
Authors: Al Hageh, Cynthia
O'Sullivan, Siobhan
Platt, Daniel E
Henschel, Andreas
Chacar, Stephanie
Gauguier, Dominique
Abche, Antoine B.
Alefishat, Eman
Nader, Moni
Zalloua, Pierre A
Affiliations: Faculty of Medicine 
Keywords: CAD
Genetic association
Rs17608766 (GOSR2)
Rs7904519 (TCF7L2)
Issue Date: 2023-12-09
Publisher: Elsevier
Part of: Diabetes Research and Clinical Practice
Volume: 207
Aims: Type 2 diabetes (T2D) and coronary artery disease (CAD) often coexist and share genetic factors. This study aimed to investigate the common genetic factors underlying T2D and CAD in patients with CAD. Methods: A three-step association approach was conducted: a) a discovery step involving 943 CAD patients with T2D and 1,149 CAD patients without T2D; b) an eliminating step to exclude CAD or T2D specific variants; and c) a replication step using the UK Biobank data. Results: Ten genetic loci were associated with T2D in CAD patients. Three variants were specific to either CAD or T2D. Five variants lost significance after adjusting for covariates, while two SNPs remained associated with T2D in CAD patients (rs7904519*G: TCF7L2 and rs17608766*C: GOSR2). The T2D susceptibility rs7904519*G was associated with increased T2D risk, while the CAD susceptibility rs17608766*C was negatively associated with T2D in CAD patients. These associations were replicated in a UK Biobank data, confirming the results. Conclusions: No significant common T2D and CAD susceptibility genetic association was demonstrated indicating distinct disease pathways. However, CAD patients carrying the T2D susceptibility gene TCF7L2 remain at higher risk for developing T2D emphasizing the need for frequent monitoring in this subgroup. © 2023
ISSN: 01688227
DOI: 10.1016/j.diabres.2023.111052
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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