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Title: Clinical, Gender, Socioeconomic Characteristics and Outcomes of Individuals Receiving Hepatitis B Treatment in Ethiopia: 18-Month Follow-Up
Authors: Tappata, Manaswita
Farah, Marina
Anugwom, Chimaobi
Bisrat, Eden
Seid, Amir S
Debes, Jose D
Affiliations: Faculty of Medicine 
Issue Date: 2023-09-11
Publisher: National Library of Medicine
Part of: The American journal of tropical medicine and hygiene
Volume: 109
Issue: 5
Start page: 1161
End page: 1165
There is a lack of real-world data on hepatitis B (HBV) treatment in Africa. We conducted a single-center 18-month prospective cohort study in Ethiopia to understand clinical, laboratory, and demographic variables associated with HBV treatment. One hundred fifty HBV-positive patients were included: 51 on treatment, 99 with no treatment. Median age was similar between groups. Those on treatment were more likely to be male (86%), report higher coffee intake (90% versus 70%, P < 0.05), lower khat intake (0% versus 9%, P = 0.08), lower alcohol consumption (0% versus 5%, P = 0.1), and had attained higher levels of education (56% versus 42%, P = 0.19). Individuals on treatment had higher median aspartate aminotransferase (AST), alanine aminotransferase (ALT), HBV DNA, and median Aminotransferase-to-Platelet Ratio Index and Fibrosis-4 scores. At 6 and 12 months, those on treatment showed a decrease in median AST, ALT, and fibrosis scores and had less hepatocellular carcinoma development at 6 months (2% versus 4%). Our study highlights potential demographic disparities in HBV treatment as well as benefits in a real-life setting in Africa.
DOI: 10.4269/ajtmh.23-0236
Type: Journal Article
Appears in Collections:Faculty of Medicine

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