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Title: Outcomes of Laparotomic Myomectomy during Pregnancy for Symptomatic Uterine Fibroids: A Prospective Cohort Study
Authors: Babunashvili, Evgeniya Leonidovna
Son, Danil Yurievich
Buyanova, Svetlana Nikolaevna
Schukina, Natalya Alekseevna
Popov, Alexander Anatolyevich
Chechneva, Marina Alexandrovna
Glebov, Timur Alekseevich
D'Amato, Antonio
Haydamous, Joe
Chiantera, Vito
Laganà, Antonio Simone
Etrusco, Andrea
Affiliations: Faculty of Medicine 
Keywords: Maternal–fetal outcomes
Uterine fibroids
Issue Date: 2023-10-08
Publisher: MDPI
Part of: Journal of Clinical Medicine
Volume: 12
Issue: 19
Background: The incidence of pregnant women with uterine fibroids is increasing. As they are reactive to hormonal stimuli, in some cases, uterine fibroids tend to grow during pregnancy and potentially generate symptoms with different levels of severity, causing maternal-fetal complications. In very select cases, when other treatment strategies fail to manage symptoms and there is a substantial risk of adverse pregnancy outcomes, a surgical approach during pregnancy may be considered. Methods: From 2016 to 2021, the data from 28 pregnant women with symptomatic uterine fibroids who underwent laparotomic myomectomy during pregnancy were prospectively collected, and operative and maternal-fetal outcomes were analyzed (ClinicalTrial ID: NCT06009562). Results: The procedure was carried out between 14 and 16 weeks of pregnancy. Four (14.3%) patients had intraoperative complications (miscarriages) and nine (32.1%) had postoperative complications (threatened preterm birth). Overall, 24 (85.7%) women delivered at full term (mean: 38.2 gestational weeks), more than half (n = 13; 54.2%) by vaginal delivery, with normal fetal weights and 1 and 5 min Apgar scores. Conclusions: Laparotomic myomectomy during pregnancy can be considered in selected cases for uterine fibroids with severe symptoms when other treatment options have failed and there is high risk of adverse maternal-fetal outcomes.
ISSN: 2077-0383
DOI: 10.3390/jcm12196406
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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