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Title: The dynamic relationship of gut microbiota with sex hormones in systemic lupus erythematosus
Authors: Katrib, Marcel
Haddad, Rafi
Hamdan, Zahi
Rida, Mohamad Ali
Affiliations: Department of Medical Laboratory Sciences 
Faculty of Medicine 
Keywords: Autoimmunity
Gut microbiota
Molecular mimicry
Sex hormones
Systemic lupus erythematosus
Issue Date: 2023-05-10
Publisher: National Library of Medicine
Part of: Reumatologia
Volume: 61
Issue: 2
Start page: 130
End page: 136
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease. The sex hormones estrogen and testosterone may have an influence on the production of antibodies. In addition, the gut microbiota also shows an effect on the onset and progression of SLE. Hence, the molecular interplay between sex hormones in terms of gender difference, gut microbiota and SLE is being clarified day after day. The aim of this review is to investigate the dynamic relationship of the gut microbiota with sex hormones in systemic lupus erythematosus taking into account the bacterial strains shown to be affected, effects of antibiotics and other factors that affect the gut microbiome, which itself strongly affects the pathogenesis of SLE.
ISSN: 0034-6233
DOI: 10.5114/reum/163091
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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