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Title: Liquid biopsies and minimal residual disease in lymphoid malignancies
Authors: Bou Zerdan, Maroun
Kassab, Joseph
Saba, Ludovic
Haroun, Elio
Bou Zerdan, Morgan
Allam, Sabine
Nasr, Lewis
Macaron, Walid
Mammadli, Mahinbanu
Abou Moussa, Sarah
Chaulagain, Chakra P
Affiliations: Faculty of Medicine 
Keywords: Liquid biopsy
Lymphoid malignancies
Minimal residual disease
Multiple myeloma
Issue Date: 2023-05-09
Publisher: National Library of Medicine
Part of: Frontiers in Oncology
Volume: 13
Minimal residual disease (MRD) assessment using peripheral blood instead of bone marrow aspirate/biopsy specimen or the biopsy of the cancerous infiltrated by lymphoid malignancies is an emerging technique with enormous interest of research and technological innovation at the current time. In some lymphoid malignancies (particularly ALL), Studies have shown that MRD monitoring of the peripheral blood may be an adequate alternative to frequent BM aspirations. However, additional studies investigating the biology of liquid biopsies in ALL and its potential as an MRD marker in larger patient cohorts in treatment protocols are warranted. Despite the promising data, there are still limitations in liquid biopsies in lymphoid malignancies, such as standardization of the sample collection and processing, determination of timing and duration for liquid biopsy analysis, and definition of the biological characteristics and specificity of the techniques evaluated such as flow cytometry, molecular techniques, and next generation sequencies. The use of liquid biopsy for detection of minimal residual disease in T-cell lymphoma is still experimental but it has made significant progress in multiple myeloma for example. Recent attempt to use artificial intelligence may help simplify the algorithm for testing and may help avoid inter-observer variation and operator dependency in these highly technically demanding testing process.
ISSN: 2234-943X
DOI: 10.3389/fonc.2023.1173701
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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