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Title: Role of Insulin Clearance in Insulin Action and Metabolic Diseases
Authors: Ghadieh, Hilda 
Gastaldelli, Amalia
Najjar, Sonia M
Affiliations: Faculty of Medicine 
Issue Date: 2023-04-12
Publisher: National Library of Medicine
Part of: International Journal of Molecular Sciences
Volume: 24
Issue: 8
The year 2021 marked the centenary of the discovery of insulin. Since its discovery,
investigations have focused on how insulin secretion from pancreatic beta cells triggers
branching signaling pathways to mediate its physiological actions. Secreted in pulses
into the portal circulation, insulin binds to cell surface receptors on hepatocytes through
fenestrations of endothelial cells lining the hepatic sinusoid. This triggers its rapid receptormediated internalization and targeting for degradation to be cleared from circulation.
Insulin degradation constitutes the basic mechanism of hepatic insulin clearance. In recent
years, this process has gained traction since it has been found to contribute to determining
the physiologic levels of insulin reaching post-hepatic tissues and, subsequently, regulate systemic insulin action. This Special Issue, entitled “Role of Insulin Clearance in
Insulin Action and Metabolic Diseases”, focuses on the body of work delineating the
molecular mechanisms of altered insulin clearance and its role in the pathogenesis of
dysregulated metabolism.
ISSN: 16616596
DOI: 10.3390/ijms24087156
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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