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Title: Loss of CEACAM1 in endothelial cells causes hepatic fibrosis
Authors: Muturi, Harrison T
Ghadieh, Hilda 
Abdolahipour, Raziyeh
Stankus, Hannah L
Belew, Getachew Debas
Liu, James K
Jahromi, Marziyeh Salehi
Lee, Abraham D
Singer, Bernhard B
Angeli-Pahim, Isabella
Sehrawat, Tejasav S
Malhi, Harmeet
Verhulst, Stefaan
van Grunsven, Leo A
Zarrinpar, Ali
Duarte, Sergio
Najjar, Sonia M
Affiliations: Faculty of Medicine 
Keywords: Endothelial cells
Hepatic stellate cells
Issue Date: 2023-07
Publisher: Elsevier
Part of: Metabolism: Clinical and Experimental
Volume: 144
Hepatocytic CEACAM1 plays a critical role in NASH pathogenesis, as bolstered by the development of insulin resistance, visceral obesity, steatohepatitis and fibrosis in mice with global Ceacam1 (Cc1) deletion. In contrast, VECadCre+Cc1fl/fl mice with endothelial loss of Cc1 manifested insulin sensitivity with no visceral obesity despite elevated NF-κB signaling and increased systemic inflammation. We herein investigated whether VECadCre+Cc1fl/fl male mice develop hepatic fibrosis and whether this is mediated by increased production of endothelin1 (ET1), a transcriptional NF-κB target.
ISSN: 00260495
DOI: 10.1016/j.metabol.2023.155562
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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