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Title: Protective Role and Functional Engineering of Neuropeptides in Depression and Anxiety: An Overview
Authors: Okdeh, Nathalie
Mahfouz, Georges
Harb, Julien
Sabatier, Jean-Marc
Roufayel, Rabih
Gazo Hanna, Eddie
Kovacic, Hervé
Fajloun, Ziad
Affiliations: Faculty of Medicine 
Keywords: Anxiety
Gut–brain peptide
Opioid peptide
Pituitary hormone peptide
Issue Date: 2023-02-16
Publisher: National Library of Medicine
Part of: Bioengineering
Volume: 10
Issue: 2
Behavioral disorders, such as anxiety and depression, are prevalent globally and touch children and adults on a regular basis. Therefore, it is critical to comprehend how these disorders are affected. It has been demonstrated that neuropeptides can influence behavior, emotional reactions, and behavioral disorders. This review highlights the majority of the findings demonstrating neuropeptides' behavioral role and functional engineering in depression and anxiety. Gut-brain peptides, hypothalamic releasing hormone peptides, opioid peptides, and pituitary hormone peptides are the four major groups of neuropeptides discussed. Some neuropeptides appear to promote depression and anxiety-like symptoms, whereas others seem to reduce it, all depending on the receptors they are acting on and on the brain region they are localized in. The data supplied here are an excellent starting point for future therapy interventions aimed at treating anxiety and depression.
ISSN: 2306-5354
DOI: 10.3390/bioengineering10020258
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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