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Title: The Influence of Female Reproductive Factors on Longevity: A Systematized Narrative Review of Epidemiological Studies
Authors: Costanian, Christy
Farah, Raymond
Salameh, Ray
Meisner, Brad A
Aoun Bahous, Sola
Sibai, Abla M
Affiliations: Faculty of Medicine 
Keywords: Female reproductive factors
Reproductive factors
Issue Date: 2022-11-18
Part of: Gerontology and Geriatric Medicine
Volume: 8
Purpose: This systematized review presents a synthesis of epidemiological studies that examine the association between female reproductive factors and longevity indicators. Methods: A comprehensive literature search was conducted using four bibliographic databases: OVID Medline, Web of Science, PubMed, and Google Scholar, including English language articles published until March 2022. Results from the search strategy yielded 306 articles, 37 of which were included for review based on eligibility criteria. Results were identified within the following nine themes: endogenous androgens and estrogens, age at first childbirth, age at last childbirth, parity, reproductive lifespan, menopause-related factors, hormone therapy use, age at menarche, and offspring gender. Results: Evidence that links reproductive factors and long lifespan is limited. Several female reproductive factors are shown to be significantly associated with longevity, yet findings remain inconclusive. The most consistent association was between parity (fertility and fecundity) and increased female lifespan. Age at first birth and parity were consistently associated with increased longevity. Associations between age at menarche and menopause, premature menopause, reproductive lifespan, offspring gender and longevity are inconclusive. Conclusion: There is not enough evidence to consider sex a longevity predictor. To understand the mechanisms that predict longevity outcomes, it is imperative to consider sex-specific within-population differences.
ISSN: 2333-7214
DOI: 10.1177/23337214221138663
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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