Please use this identifier to cite or link to this item:
Title: Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms
Authors: Haidar, Muhammad Ali
Ibeh, Stanley
Shakkour, Zaynab
Reslan, Mohammad Amine
Nwaiwu, Judith
Moqidem, Yomna Adel
Sader, Georgio
Nickles, Rachel G
Babale, Ismail
Jaffa, Aneese A.
Salama, Mohamed
Shaito, Abdullah
Affiliations: Faculty of Medicine 
Keywords: Cellular crosstalk
CNS Injury
Microglia phenotypes
Microglia-neuron interaction
Microglial activation
Issue Date: 2022
Publisher: National Library of Medicine
Part of: Current neuropharmacology
Volume: 20
Issue: 11
Start page: 2050
End page: 2065
Microglia are the resident immune cells of the brain and play a crucial role in housekeeping and maintaining homeostasis of the brain microenvironment. Upon injury or disease, microglial cells become activated, at least partly, via signals initiated by injured neurons. Activated microglia, thereby, contribute to both neuroprotection and neuroinflammation. However, sustained microglial activation initiates a chronic neuroinflammatory response which can disturb neuronal health and disrupt communications between neurons and microglia. Thus, microglia-neuron crosstalk is critical in a healthy brain as well as during states of injury or disease. As most studies focus on how neurons and microglia act in isolation during neurotrauma, there is a need to understand the interplay between these cells in brain pathophysiology. This review highlights how neurons and microglia reciprocally communicate under physiological conditions and during brain injury and disease. Furthermore, the modes of microglia-neuron communication are exposed, focusing on cell-contact dependent signaling and communication by the secretion of soluble factors like cytokines and growth factors. In addition, it has been discussed that how microglia-neuron interactions could exert either beneficial neurotrophic effects or pathologic proinflammatory responses. We further explore how aberrations in microglia-neuron crosstalk may be involved in central nervous system (CNS) anomalies, namely traumatic brain injury (TBI), neurodegeneration, and ischemic stroke. A clear understanding of how the microglia-neuron crosstalk contributes to the pathogenesis of brain pathologies may offer novel therapeutic avenues of brain trauma treatment.
DOI: 10.2174/1570159X19666211202123322
Type: Journal Article
Appears in Collections:Faculty of Medicine

Show full item record

Record view(s)

checked on Dec 7, 2022

Google ScholarTM


Dimensions Altmetric

Dimensions Altmetric

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.