Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/6210
Title: AhRR methylation contributes to disease progression in urothelial bladder cancer
Authors: El-Haddad, Nataly W
El Kawak, Michelle
El Asmar, Khalil
Jabbour, Michel E
Moussa, Mohamad A
Habib, Rima R
Dhaini, Hassan R
Affiliations: Faculty of Medicine 
Keywords: FGFR3
Urothelial bladder cancer
Methylation
Muscle-invasiveness
p53
Tobacco smoking
Issue Date: 2022-10-12
Publisher: National Library of Medicine
Part of: Cancer biomarkers : section A of Disease markers
Volume: 35
Issue: 2
Start page: 167
End page: 177
Abstract: 
Bladder Cancer (BCa) is the tenth most incident malignancy worldwide. BCa is mostly attributed to environmental exposure and lifestyle, particularly tobacco smoking. The Aryl Hydrocarbon Receptor Repressor (AhRR) participates in the induction of many enzymes involved in metabolizing carcinogens, including tobacco smoke components. Additionally, studies have shown that smoking demethylates the (AhRR) gene in blood, suggesting AhRR demethylation as a specific serum smoking biomarker.
URI: https://scholarhub.balamand.edu.lb/handle/uob/6210
DOI: 10.3233/CBM-220002
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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