Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/6136
Title: Single Cell RNA Sequencing: A New Frontier in Pancreatic Ductal Adenocarcinoma
Authors: Bou Zerdan, Maroun
Shatila, Malek
Sarwal, Dhruv
Bouferraa, Youssef
Bou Zerdan, Morgan
Allam, Sabine
Ramovic, Merima
Graziano, Stephen
Affiliations: Faculty of Medicine 
Keywords: Fibroblasts
Pancreatic ductal adenocarcinoma
Single cell RNA sequencing
Transcriptomes
Issue Date: 2022-01-22
Publisher: National Library of Medicine
Part of: Cancers
Volume: 14
Issue: 19
Abstract: 
Simple Summary
Pancreatic cancer has a very low survival rate for several reasons. One of those is primarily due to the difficulty in diagnosing it at an early stage. For this reason, it is important to refine our understanding of this disease to guide the development of new diagnostic and therapeutic modalities to combat this fatal illness. Here we attempt to provide a review of current progress in utilizing single-cell RNA sequencing (scRNA-seq) techniques in the molecular profiling of pancreatic ductal adenocarcinoma.

Abstract
Pancreatic ductal adenocarcinoma is a malignancy with a high mortality rate. It exhibits significant heterogeneity in metabolic pathways which are associated with its progression. In this review, we discuss the role of single cell RNA sequencing in unraveling the metabolic and clinical features of these highly malignant tumors.
URI: https://scholarhub.balamand.edu.lb/handle/uob/6136
ISSN: 2072-6694
DOI: 10.3390/cancers14194589
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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