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|Title:||Susceptibility trends and molecular characterization of Gram-negative bacilli associated with urinary tract and intra-abdominal infections in Jordan and Lebanon: SMART 2011-2013||Authors:||Hayajneh, Wail A
Sarkis, Dolla Karam
Badal, Robert E
|Affiliations:||Faculty of Medicine||Keywords:||Beta-lactamases
Urinary tract infection
|Issue Date:||2015||Part of:||International Journal of Infectious Diseases||Volume:||35||Issue:||e56||Start page:||e61||Abstract:||
To investigate phenotypic and genotypic patterns of antimicrobial resistance among Gram-negative bacilli associated with urinary tract infection (UTI) and intra-abdominal infection (IAI) in medical centres of Jordan and Lebanon.
Gram-negative bacilli from the SMART study, collected between the years 2011 and 2013, were first identified at local laboratories. These isolates were shipped to a central laboratory where re-identification, susceptibility testing, and molecular characterization were performed using standard methods.
Among the 523 UTI-associated isolates, Escherichia coli , Klebsiella pneumoniae , and Proteus mirabilis were the most frequent (70%, 14%, and 5%, respectively). E. coli , K. pneumoniae , and Pseudomonas aeruginosa were the most frequent species among the 527 IAI-associated isolates (46%, 14%, and 12%, respectively). Incidence rates of extended-spectrum beta-lactamase (ESBL) producers among UTI-associated E. coli , K. pneumoniae , and P. mirabilis were 43%, 54%, and 4%, respectively. Corresponding rates among IAI-associated isolates were 49%, 56%, and 12%, respectively. Acinetobacter baumannii and P. aeruginosa isolates showed very disturbing low susceptibility patterns. CTX-M-15 was the most prevalent ESBL produced. Seventeen isolates were non-susceptible to carbapenems (estimated prevalence of 1.6%).
The alarmingly high rates of ESBL production and emergence of carbapenemases emphasize the urgent need to develop antimicrobial stewardship initiatives and to maintain antimicrobial resistance surveillance systems.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/6014||ISSN:||12019712||DOI:||10.1016/j.ijid.2015.04.011||Open URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Faculty of Medicine|
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