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Title: Valproate-induced enuresis: a prospective study
Authors: Yamak, Wissam R
Hmaimess, Ghassan
Makke, Yamane
Sabbagh, Sandra
Arabi, Maher
Beydoun, Ahmad
Nasreddine, Wassim
Affiliations: Faculty of Medicine 
Issue Date: 2015
Publisher: National Library of Medicine
Part of: Developmental Medicine and Child Neurology
Volume: 57
Issue: 8
Start page: 737
End page: 741
The aim of this study was to determine the frequency and characteristics of secondary enuresis in children initiated on valproate treatment.

This was a prospective study conducted in children aged 5 to 12 years with suspected newly diagnosed epilepsy and maintained on valproate for at least 1 month. Adverse events spontaneously reported by parents were recorded at each follow-up visit. In addition, we specifically asked about enuresis and other side effects known to occur with valproate treatment. We assessed the frequency of enuresis and its association with a number of variables.

Seventy-two children (43 males and 29 females) with a mean age of 8 years 7 months (range 5–12y) were included in this study. Secondary enuresis developed in 17 (24%) of these children after, on average, 19.8 days of exposure to valproate. The data obtained from a multivariate analysis indicate that age was the only significant factor in predicting the development of enuresis. Enuresis ceased in all children after discontinuation of valproate use, and in 10 out of 11 children still on the drug.

Secondary enuresis is a common adverse event associated with valproate use in children, which is not usually spontaneously reported and is reversible in most cases.
ISSN: 00121622
DOI: 10.1111/dmcn.12737
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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