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Title: Safety of a thickened extensive casein hydrolysate formula
Authors: Vandenplas, Yvan
De Greef, Elisabeth
Xinias, I
Vrani, O
Mavroudi, A
Hammoud, M
Al Refai, F
Khalife, M C
Sayad, A
Noun, P
Farah, A
Makhoul, G
Orel, R
Sokhn, Maroun
L'Homme, A
Mohring, M P
Merhi, B Abou
Boulos, J
El Masri, H
Halut, C
Affiliations: Faculty of Medicine 
Keywords: (Extensive) hydrolysate
Antiregurgitation formula
Cow's milk allergy
Infant nutrition
Thickened formula
Issue Date: 2016
Part of: Nutrition
Volume: 3
Issue: 2
Start page: 206
End page: 212
Cow's milk allergy (CMA) is treated in formula-fed infants with an extensive protein hydrolysate. This study aimed to evaluate the nutritional safety of a non-thickened and thickened extensively casein hydrolyzed protein formula (NT- and T-eCHF) in infants with CMA.

Infants younger than 6 mo old with a positive cow milk challenge test, positive IgE, or skin prick test for cow milk were selected. Weight and length were followed during the 6 mo intervention with the NT-eCHF and T-eCHF.

A challenge was performed in 50/71 infants with suspected CMA and was positive in 34/50. All children with confirmed CMA tolerated the eCHF. The T-eCHF leads to a significant improvement of the stool consistency in the whole population and in the subpopulation of infants with proven CMA. Height and weight evolution was satisfactory throughout the 6 mo study.

The eCHF fulfills the criteria of a hypoallergenic formula and the NT- and T-eCHF reduced CMA symptoms. Growth was within normal range.
ISSN: 08999007
DOI: 10.1016/j.nut.2015.08.008
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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