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Title: Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values
Authors: Akiki, Zeina
Fakih, Dalia
Jounblat, Rania
Chamat, Soulaima
Waked, Mirna
Holmskov, Uffe
Sorensen, Grith L.
Nadif, Rachel
Salameh, Pascale
Affiliations: Faculty of Medicine 
Keywords: Serum surfactant protein D
Serum C-reactive protein
Plasma fibrinogen
Chronic obstructive pulmonary disease
Issue Date: 2016
Publisher: National Library of Medicine
Part of: Experimental and Therapeutic Medicine
Volume: 11
Issue: 3
Start page: 723
End page: 730
Biological markers can help to better identify a disease or refine its diagnosis. In the present study, the association between surfactant protein D (SP-D) and chronic obstructive pulmonary disease (COPD) was studied among subjects consulting for respiratory diseases or symptoms and was compared with C-reactive protein (CRP) and fibrinogen. A further aim of this study was to identify the optimal cut-off point of SP-D able to discriminate COPD patients. A case-control study including 90 COPD patients, 124 asthma patients and 180 controls was conducted. Standardized questionnaires were administered and lung function tests were performed. Biological markers were measured in blood samples according to standardized procedures. The association between SP-D and COPD was investigated using logistic regression models. Receiver-operating characteristic curves were used for threshold identification. SP-D levels above the median value were positively associated with COPD [adjusted odds ratio (OR)=3.86, 95% confidence interval (CI): 1.51–9.85, P=0.005). No associations with COPD or asthma were found for CRP or fibrinogen levels. Scores for COPD diagnosis in all COPD patients or ever-smoker COPD patients were identified (sensitivity, 76.4 and 77.8%; specificity, 89.3 and 88.5%, respectively). The results indicate that SP-D can differentiate COPD from other respiratory symptoms or diseases. Used with socio-demographic characteristics and respiratory symptoms, SP-D is able to discriminate COPD patients from controls, particularly among smokers.
DOI: 10.3892/etm.2016.2986
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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