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Title: Extra-pulmonary applications of procalcitonin: an updated literature review
Authors: Atallah, Christine J
Panossian, Vahe S
Atallah, Natalie J
Roberts, Matthew B
Mansour, Michael K
Affiliations: Faculty of Medicine 
Keywords: Procalcitonin
Issue Date: 2022-07-13
Publisher: Taylor & Francis Online
Part of: Expert Review of Molecular Diagnostics
Volume: 22
Issue: 5
Start page: 537
End page: 544
Procalcitonin (PCT) is a biomarker with established performance in the differentiation between bacterial and viral infections, predominantly in pulmonary infections, as well as the diagnosis and prognosis of bacterial sepsis. However, the role of PCT in extra-pulmonary infections is not well described.

Areas Covered
We reviewed the role of PCT in commonly experienced extra-pulmonary infections including meningitis, diabetic foot infection, prosthetic joint infection, osteomyelitis, and skin and soft tissue infection. PubMed and Medline online libraries were searched, from 2013 till 2022, for relevant articles.

Expert Opinion
For meningitis, PCT could distinguish bacterial from viral meningitis. PCT distinguished septic arthritis from different inflammatory states but had variable performance in discriminating septic arthritis from crystal arthropathy. For periprosthetic joint infections, results were inconclusive. PCT had a potential role in diagnosis of more complex infections such as osteomyelitis and diabetic foot infections, but further studies are needed for a definitive cutoff. In skin and soft tissue infections, PCT performance was variable requiring further investigation to define cutoff for the discrimination of cellulitis from necrotizing fasciitis. We find that PCT performed best for meningitis and helps in the reduction of unnecessary antibiotic treatment, but has variable outcomes with other extra-pulmonary infections.
ISSN: 14737159
DOI: 10.1080/14737159.2022.2094705
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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