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Title: Mass Spectrometry Imaging Can Distinguish on a Proteomic Level Between Proliferative Nodules Within a Benign Congenital Nevus and Malignant Melanoma
Authors: Lazova, Rossitza
Yang, Zhe
El Habr, Constantin
Lim, Young
Choate, Keith Adam
Seeley, Erin H
Caprioli, Richard M
Yangqun, Li
Affiliations: Faculty of Medicine 
Keywords: Congenital melanocytic nevus
Malignant melanoma
Mass spectrometry
Mass spectrometry imaging
Proliferative nodule, congenital melanoma
Issue Date: 2017
Publisher: National Library of Medicine
Part of: American Journal of Dermatopathology
Volume: 39
Issue: 9
Start page: 689
End page: 695
Histopathological interpretation of proliferative nodules occurring in association with congenital melanocytic nevi can be very challenging due to their similarities with congenital malignant melanoma and malignant melanoma arising in association with congenital nevi. We hereby report a diagnostically challenging case of congenital melanocytic nevus with proliferative nodules and ulcerations, which was originally misdiagnosed as congenital malignant melanoma. Subsequent histopathological examination in consultation by one of the authors (R.L.) and mass spectrometry imaging analysis rendered a diagnosis of congenital melanocytic nevus with proliferative nodules. In this case, mass spectrometry imaging, a novel method capable of distinguishing benign from malignant melanocytic lesions on a proteomic level, was instrumental in making the diagnosis of a benign nevus. We emphasize the importance of this method as an ancillary tool in the diagnosis of difficult melanocytic lesions.
ISSN: 01931091
DOI: 10.1097/DAD.0000000000000849
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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