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Title: Pediatric collagenous gastritis and colitis: A case series and review of the literature
Authors: Matta, Judy
Alex, George
Cameron, Donald J.S.
Chow, Chung W.
Hardikar, Winita
Heine, Ralf G.
Affiliations: Faculty of Medicine 
Keywords: Abdominal pain
Iron deficiency anemia
Issue Date: 2018-01-01
Part of: Journal of Pediatric Gastroenterology and Nutrition
Volume: 67
Issue: 3
Start page: 328
End page: 334
Collagenous gastritis is a rare disease characterized by the subepithelial deposition of collagen bands. Two phenotypes of the disease have been described: a pediatric-onset and an adult-onset type. The adult-onset form is associated with collagenous colitis and autoimmune disorders. No effective treatment has been identified to date.

We aim to describe the clinical features and outcomes of patients in our cohort and provide a summary of published pediatric cases with collagenous gastritis and colitis reported to date to gather information that will contribute to improved knowledge of this rare condition.

A retrospective chart review of all patients with collagenous gastritis and/or colitis who were treated at the Royal Children's Hospital, Melbourne, was performed. A literature review was also conducted.

A total of 12 cases of collagenous gastritis were reviewed. Three of 12 (25%) patients had associated collagenous colitis. The most common clinical presentation was iron deficiency anemia. Nine (75%) patients were followed up, and repeat endoscopies were performed in 8 (67%). Iron deficiency anemia resolved in all patients on oral iron supplementation. Histologic improvement was only identified in one patient with the adult phenotype who had been treated with oral corticosteroids and azathioprine.

Collagenous gastritis is a rare condition in children. A small proportion of children develop features of the “‘adult” phenotype at a very young age. Patients with collagenous gastritis require long-term follow-up and monitoring of their disease. Further randomized clinical trials are needed to establish an effective therapeutic strategy.
ISSN: 02772116
DOI: 10.1097/MPG0000000000001975
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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