Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/5751
Title: New insights into the pathogenesis of intradialytic hypertension
Authors: Hajal, Joelle
Saliba, Youakim
Joubran, Najat
Sleilaty, Ghassan
Chacra, Dima
Assaad, Shafika
Chelala, Dania
Farès, Nassim
Affiliations: Faculty of Medicine 
Keywords: Blood pressure
Endothelial dysfunction
Hemodialysis
Intradialytic hypertension
Kidney
Nitric oxide
Issue Date: 2018-01-01
Part of: Open Urology and Nephrology Journal
Volume: 11
Issue: 1
Start page: 87
End page: 99
Abstract: 
Background:
Intradialytic hypertension is identified as an independent predictor of adverse clinical outcome in hemodialysis patients. Little is known about its pathophysiological mechanism.

Objective:
The aim of this study is to provide new insights into the mechanisms underlying this arterial pressure dysregulation.

Methods:
62 subjects on chronic hemodialysis were included in this study. Blood pressure was monitored before, during and following each dialysis session for a 3-month period. Pre- and post-dialysis blood samples were drawn from all the subjects to perform immunoassays, monocyte extractions and western blot analyses.

Results:
Blood pressure values separated the subjects with in two groups: normal blood pressure (n=53) and intradialytic hypertension (n=9) groups. Renin, angiotensin converting enzyme I and aldosterone plasma concentrations significantly diverged between the groups. Vascular endothelial nitric oxide assessment revealed significantly lower plasma L-citrulline and angiotensin-converting enzyme II in post-dialysis intradialytic hypertensive patients, along with high endothelin I and asymmetric dimethylarginine concentrations. Plasma collectrin levels were significantly higher in pre and post-dialysis intradialytic hypertensive group compared to a normal blood pressure group. Post-dialysis interleukin 6 was significantly higher in intradialytic hypertensive group compared to normal blood pressure group. Finally, pre-dialysis intradialytic hypertension was associated with significantly higher circulating vascular endothelial growth factor C with monocytic up-regulation of vascular endothelial growth factor C/tonicity-responsive enhancer binding protein expression.

Conclusion:
Impairment of vascular endothelial nitric oxide key regulatory elements, as well as monocytic vascular endothelial growth factor C seems to be more prevalent in intradialytic hypertension. These clues could pinpoint novel therapeutic interventions in intradialytic hypertension management.
URI: https://scholarhub.balamand.edu.lb/handle/uob/5751
DOI: 10.2174/1874303X01811010087
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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