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Title: Colonic Malakoplakia: A Rare Finding in a Healthy Male
Authors: Yared, Rawad A.
Badran, Hussein A.
Kamareddine, Mohammed Hussein
Ghosn, Youssef
Bou Khalil, Roula
El Ajamy, Khaled
Chouairy, Camil
Farhat, Said G.
Affiliations: Faculty of Medicine 
Keywords: Gastrointestinal tract
Transverse colon
Issue Date: 2018-01-01
Part of: Case Reports in Gastroenterology
Volume: 12
Issue: 2
Start page: 453
End page: 456
Malakoplakia is a rare chronic granulomatous disease that may affect many organs, including the lung, brain, adrenal glands, pancreas, bone, and the genitourinary tract. The gastrointestinal tract is the most common site of involvement outside of the urinary tract. Herein, we present a case of a 65-year-old male who presented with abdominal pain and unintentional weight loss. Physical examination findings were unremarkable, but colonoscopy revealed an isolated large, flat, soft, and pale lesion in the transverse colon. Histopathological examination of the lesion showed expansion of the lamina propria due to numerous lymphocytes, plasma cells, neutrophils, and polygonal cells. Von Kossa stain showed small intracytoplasmic basophilic granular inclusions, and these histiocyte cells showed numerous Michaelis-Gutmann bodies, findings considered as diagnostic features of colonic malakoplakia. This is a rare case of isolated malakoplakia of the transverse colon diagnosed on endoscopic specimens. The majority of reported cases have shown an association between systemic diseases and colorectal adenocarcinoma. In addition, most reported cases of colonic involvement have been in the rectum, sigmoid, and right colon.
DOI: 10.1159/000492208
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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