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Title: Management of leptomeningeal metastasis in breast cancer
Authors: Assi, Hazem I
Mahmoud, Tala
Saadeh, Fadi S
El Darsa, Haidar
Affiliations: Faculty of Medicine 
Keywords: Brain cancer
Breast cancer
Carcinomatous meningitis
Leptomeningeal metastasis
Issue Date: 2018
Publisher: Elsevier
Part of: Clinical Neurology and Neurosurgery
Volume: 172
Start page: 151
End page: 159
Leptomeningeal metastasis (LM), which occurs when malignant cells spread to the central nervous system, is becoming an increasingly common complication in patients with breast cancer. Diagnosis and treatment of LM is challenging. Moreover, prognosis of patients with LM is poor, with a median survival of 6 months after diagnosis. This review highlights the strengths and limitations of currently available diagnostic tools and therapies for LM. The current treatments for LM, including radiotherapy, systemic therapy, and intrathecal treatment, aim to maintain the quality of life of patients by correcting neurological deficits and arresting neurological degeneration. However, there is no standardized therapy for LM because of a lack of randomized trials on this condition.
ISSN: 03038467
DOI: 10.1016/j.clineuro.2018.07.001
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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