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Title: Adenoma Detection before and after the age of 50: A retrospective analysis of Lebanese outpatients
Authors: Hussein Kamareddine, Mohammed
Ghosn, Youssef
Karam, Karam
Nader, Anwar Andrew
El-Mahmoud, Ahmad
Bou-Ayash, Naseem
El-Khoury, Mansour
Farhat, Said
Affiliations: Faculty of Medicine 
Keywords: Colon carcinogenesis
Colonic adenomas
Colonic neoplasms
Issue Date: 2018
Part of: BMJ Open Gastroenterology
Volume: 5
Issue: 1
Background and aim Colorectal cancer (CRC) has an increased impact on the Lebanese population’s morbidity and mortality. This study evaluated the situation of adenoma detection in an outpatient clinic in Lebanon.

Patients and methods 918 patients underwent colonoscopy over a period of 24 months by a qualified physician. Biopsy results were divided into normal versus abnormal colonic tissue, which was further subdivided into number of polyps and cancer.

Results Out of 918 individuals included, 82 cases of Crohn’s colitis (8.93%) and 22 cases of ulcerative colitis (2.39%) were identified. A total of 42 cases of CRC (4.58%) and 188 cases of adenomatous polyps (20.48%) were identified. The data show that age >50 years and male gender significantly correlate with increased incidence of precancerous and cancerous polyps. Further exploring the results by age groups and gender, detection of adenomatous polyps in women aged 40–49 (8.33%) was significantly different from their female counterparts aged ≥50 years old (25.26%) (p<0.01). However, no statistical difference between detection of adenomas was found between men aged 40–49 (33.33%) and their male counterparts aged ≥50 years old (37.5%) (p=0.6).

Conclusion Within the limitations of this study, the incidence of CRC and adenomatous polyps falls in the high range compared with international studies. Furthermore, symptomatic male patients aged 40–49 appear to exhibit detection rates of adenomas similar to their counterparts aged ≥50 years old. Subjects younger than 50 years underwent diagnostic rather than screening colonoscopy, which introduces some selection bias. Nevertheless, these findings can serve as a basis for further studies.
DOI: 10.1136/bmjgast-2018-000253
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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