Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/5650
Title: VEGF-C attenuates renal damage in salt-sensitive hypertension
Authors: Beaini, Shadia
Saliba, Youakim
Hajal, Joelle
Smayra, Viviane
Bakhos, Jules-Joel
Joubran, Najat
Chelala, Dania
Fares, Nassim
Affiliations: Faculty of Medicine 
Keywords: NOS3
Kidney
Renal lymphangiogenesis
Salt-sensitive hypertension
Skin lymphangiogenesis
Vascular endothelial growth factor C (VEGF-C)
Issue Date: 2019
Publisher: National Library of Medicine
Part of: Journal of Cellular Physiology
Volume: 234
Issue: 6
Start page: 9616
End page: 9630
Abstract: 
Salt-sensitive hypertension is a major risk factor for renal impairment leading to chronic kidney disease. High-salt diet leads to hypertonic skin interstitial volume retention enhancing the activation of the tonicity-responsive enhancer-binding protein (TonEBP) within macrophages leading to vascular endothelial growth factor C (VEGF-C) secretion and NOS3 modulation. This promotes skin lymphangiogenesis and blood pressure regulation. Whether VEGF-C administration enhances renal and skin lymphangiogenesis and attenuates renal damage in salt-sensitive hypertension remains to be elucidated. Hypertension was induced in BALB/c mice by a high-salt diet. VEGF-C was administered subcutaneously to high-salt-treated mice as well as control animals. Analyses of kidney injury, inflammation, fibrosis, and biochemical markers were performed in vivo. VEGF-C reduced plasma inflammatory markers in salt-treated mice. In addition, VEGF-C exhibited a renal anti-inflammatory effect with the induction of macrophage M2 phenotype, followed by reductions in interstitial fibrosis. Antioxidant enzymes within the kidney as well as urinary RNA/DNA damage markers were all revelatory of abolished oxidative stress under VEGF-C. Furthermore, VEGF-C decreased the urinary albumin/creatinine ratio and blood pressure as well as glomerular and tubular damages. These improvements were associated with enhanced TonEBP, NOS3, and lymphangiogenesis within the kidney and skin. Our data show that VEGF-C administration plays a major role in preserving renal histology and reducing blood pressure. VEGF-C might constitute an interesting potential therapeutic target for improving renal remodeling in salt-sensitive hypertension.
URI: https://scholarhub.balamand.edu.lb/handle/uob/5650
ISSN: 00219541
DOI: 10.1002/jcp.27648
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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