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Title: Prevention of Allergic Sensitization and Treatment of Cow's Milk Protein Allergy in Early Life: The Middle-East Step-Down Consensus
Authors: Vandenplas, Yvan
Al-Hussaini, Bakr
Al-Mannaei, Khaled
Al-Sunaid, Areej
Helmi Ayesh, Wafaa
El-Degeir, Manal
El-Kabbany, Nevine
Haddad, Joseph
Hashmi, Aziza
Kreishan, Furat
Tawfik, Eslam
Affiliations: Faculty of Medicine 
Keywords: Middle-East
Cow’s milk protein allergy
Infant allergy
Infant feeding
Partial hydrolysate
Issue Date: 2019-01-26
Publisher: National Library of Medicine
Part of: Nutrients
Volume: 11
Issue: 7
Allergy risk has become a significant public health issue with increasing prevalence. Exclusive breastfeeding is recommended for the first six months of life, but this recommendation is poorly adhered to in many parts of the world, including the Middle-East region, putting infants at risk of developing allergic sensitization and disorders. When breastfeeding is not possible or not adequate, a partially hydrolyzed whey formula (pHF-W) has shown proven benefits of preventing allergy, mainly atopic eczema, in children with a genetic risk. Therefore, besides stimulating breastfeeding, early identification of infants at risk for developing atopic disease and replacing commonly used formula based on intact cow milk protein (CMP) with a clinically proven pHF-W formula is of paramount importance for allergy prevention. If the child is affected by cow's milk protein allergy (CMPA), expert guidelines recommend extensively hydrolyzed formula (eHF), or an amino acid formula (AAF) in case of severe symptoms. The Middle-East region has a unique practice of utilizing pHF-W as a step-down between eHF or AAF and intact CMP, which could be of benefit. The region is very heterogeneous with different levels of clinical practice, and as allergic disorders may be seen by healthcare professionals of different specialties with different levels of expertise, there is a great variability in preventive and treatment approaches within the region itself. During a consensus meeting, a new approach was discussed and unanimously approved by all participants, introducing the use of pHF-W in the therapeutic management of CMPA. This novel approach could be of worldwide benefit.
DOI: 10.3390/nu11071444
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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