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Title: First Detection of Colistin-Resistant Klebsiella pneumoniae in Association with NDM-5 Carbapenemase Isolated from Clinical Lebanese Patients
Authors: Nawfal Dagher, Tania
Azar, Eid
Al-Bayssari, Charbel
Chamieh, Amanda S
Rolain, Jean-Marc
Affiliations: Faculty of Medicine 
Keywords: Carbapenem Resistance
Colistin resistance
Issue Date: 2019
Part of: Microbial Drug Resistance
Volume: 25
Issue: 6
Start page: 925
End page: 930
This study aims to describe the molecular mechanisms of carbapenem and colistin resistance in Klebsiella pneumoniae strains isolated from hospitalized patients in Lebanon. We report in this study the first description of NDM-5 producing carbapenem-resistant K. pneumoniae ST383, as well as the presence of two out of five isolates resistant to colistin due to mutations in the amino acid sequences of proteins (PmrB, PhoQ, and MgrB). Therefore, screening of such isolates may be effective in limiting the spread of these resistant microorganisms in hospitalized patients and within the community.
ISSN: 10766294
DOI: 10.1089/mdr.2018.0383
Type: Journal Article
Appears in Collections:Faculty of Medicine

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