Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/5636
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dc.contributor.authorAbdel-Samad, Ranaen_US
dc.contributor.authorAouad, Patricken_US
dc.contributor.authorDarwiche, Nadineen_US
dc.date.accessioned2022-05-23T06:53:33Z-
dc.date.available2022-05-23T06:53:33Z-
dc.date.issued2019-
dc.identifier.issn09594973-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/5636-
dc.description.abstractColorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide. Although targeted therapy in combination with chemotherapy in CRC prolongs the overall survival of patients with metastatic disease, acquired resistance and relapse hinder their clinical benefits. Moreover, patients with some specific genetic profile are unlikely to benefit from targeted therapy, suggesting the need for safe and effective treatment strategies. Retinoids, comprising of natural and synthetic analogs, are a class of chemical compounds that regulate cellular proliferation, differentiation, and cell death. Retinoids have been used in the clinic for several leukemias and solid tumors, either as single agents or in combination therapy. Furthermore, retinoids have shown potent chemotherapeutic and chemopreventive properties in different cancer models, including CRC. In this review, we summarize the major preclinical findings in CRC in which natural and synthetic retinoids showed promising antitumor activities and stress on the proposed mechanisms of action. Understanding of the retinoids' antitumor mechanisms would provide insights to support and warrant their development in the management of CRC.en_US
dc.language.isoengen_US
dc.publisherNational Library of Medicineen_US
dc.subjectColorectal canceren_US
dc.subjectNatural retinoidsen_US
dc.subjectPreclinical modelsen_US
dc.subjectRetinoic aciden_US
dc.subjectSynthetic retinoidsen_US
dc.titleNatural and synthetic retinoids in preclinical colorectal cancer modelsen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1097/CAD.0000000000000802-
dc.identifier.pmid31021825-
dc.identifier.scopus2-s2.0-85069889442-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85069889442-
dc.contributor.affiliationFaculty of Health Sciencesen_US
dc.description.volume30en_US
dc.description.issue7en_US
dc.description.startpage655en_US
dc.description.endpage669en_US
dc.date.catalogued2022-05-23-
dc.description.statusPublisheden_US
dc.identifier.openURLhttps://journals.lww.com/anti-cancerdrugs/Fulltext/2019/08000/Natural_and_synthetic_retinoids_in_preclinical.2.aspxen_US
dc.relation.ispartoftextAnti-Cancer Drugsen_US
Appears in Collections:Department of Medical Laboratory Sciences
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