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Title: Dermatological adverse events associated with immune checkpoint inhibitor-based combinations of anticancer therapies: a systematic review
Authors: Salloum, Antoine
Habre, Maya
Chebl, Joanna Abi
Chebl, Karen Abi
Atallah, Carl
Medawar, Georgio
Kourie, Hampig R
Affiliations: Faculty of Medicine 
Keywords: Adverse events
Combination therapy
Immune checkpoint inhibitors
Side effects
Targeted therapy
Issue Date: 2022-03-02
Publisher: Future Medicine
Part of: Immunotherapy
Volume: 14
Issue: 6
Start page: 489
End page: 503
Aim: This paper presents the reported dermatological adverse events (AEs) associated with approved combinations of immunotherapy with drugs of the same class, or in combination with targeted therapy or chemotherapy. Materials & methods: PubMed was used as an electronic database, and a total of 29 articles were reviewed which reported dermatological AEs following combination therapies with nivolumab, ipilimumab, axitinib, pembrolizumab, lenvatinib, avelumab, atezolizumab, carboplatin, etoposide, paclitaxel, bevacizumab, pemetrexed, cisplatin and durvalumab. Results: The dermatological AEs reported were mutually inclusive and the highest incidence of specific AEs was seen in the following combinations: rash in the nivolumab/ipilimumab and lenvatinib/pembrolizumab combinations, pruritus in the atezolizumab/nab-paclitaxel combination, dry skin and palmar-plantar erythrodysesthesia in the axitinib/pembrolizumab combination, and alopecia and severe skin reactions in the pembrolizumab/carboplatin/paclitaxel combination. Conclusion: Knowledge of such side effects is of benefit when choosing an optimal treatment regimen and should be integrated into the monitoring and follow-up phases of treatment.
ISSN: 1750743X
DOI: 10.2217/imt-2021-0244
Type: Journal Article
Appears in Collections:Faculty of Medicine

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