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Title: | Dermatological adverse events associated with immune checkpoint inhibitor-based combinations of anticancer therapies: a systematic review | Authors: | Salloum, Antoine Habre, Maya Chebl, Joanna Abi Chebl, Karen Abi Atallah, Carl Medawar, Georgio Kourie, Hampig R |
Affiliations: | Faculty of Medicine | Keywords: | Adverse events Chemotherapy Combination therapy Dermatological Immune checkpoint inhibitors Immunotherapy Rash Side effects Targeted therapy |
Issue Date: | 2022 | Publisher: | Future Medicine | Part of: | Immunotherapy | Volume: | 14 | Issue: | 6 | Start page: | 489 | End page: | 503 | Abstract: | Aim: This paper presents the reported dermatological adverse events (AEs) associated with approved combinations of immunotherapy with drugs of the same class, or in combination with targeted therapy or chemotherapy. Materials & methods: PubMed was used as an electronic database, and a total of 29 articles were reviewed which reported dermatological AEs following combination therapies with nivolumab, ipilimumab, axitinib, pembrolizumab, lenvatinib, avelumab, atezolizumab, carboplatin, etoposide, paclitaxel, bevacizumab, pemetrexed, cisplatin and durvalumab. Results: The dermatological AEs reported were mutually inclusive and the highest incidence of specific AEs was seen in the following combinations: rash in the nivolumab/ipilimumab and lenvatinib/pembrolizumab combinations, pruritus in the atezolizumab/nab-paclitaxel combination, dry skin and palmar-plantar erythrodysesthesia in the axitinib/pembrolizumab combination, and alopecia and severe skin reactions in the pembrolizumab/carboplatin/paclitaxel combination. Conclusion: Knowledge of such side effects is of benefit when choosing an optimal treatment regimen and should be integrated into the monitoring and follow-up phases of treatment. |
URI: | https://scholarhub.balamand.edu.lb/handle/uob/5585 | ISSN: | 1750743X | DOI: | 10.2217/imt-2021-0244 | Type: | Journal Article |
Appears in Collections: | Faculty of Medicine |
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