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Title: Efficacy of the Combined Administration of Systemic and Intra-Articular Tranexamic Acid in Total Hip Arthroplasty Secondary to Femoral Neck Fracture: A Retrospective Study
Authors: Maalouly, Joseph
Tawk, Antonios
Ayoubi, Rami
Al Rahbani, Georges Katoul
Metri, Aida
Saidy, Elias
El-Hajj, Gerard
Nehme, Alexandre
Affiliations: Faculty of Medicine 
Faculty of Medicine 
Issue Date: 2020
Publisher: National Library of Medicine
Part of: Advances in Orthopedics
Volume: 2020
Total hip arthroplasty (THA) is associated with substantial blood loss in the postoperative course. Tranexamic acid (TXA) is a potent antifibrinolytic agent, routinely administered by intravenous (IV) and topical (intra-articular, IA) route, which can possibly interrupt the cascade of events due to hemostatic irregularities close to the source of bleeding. However, scientific evidence of combined administration of TXA in THA secondary to a femoral neck fracture is still meagre. The present study aims to compare the patients who were administered combined IV and topical TXA with a control group in terms of blood loss, transfusion rate, and incidence of deep vein thrombosis (DVT) and thromboembolism (TE). Patients and Methods. 195 patients with femoral neck fracture underwent THA and were placed into two groups: (1) IV and IA TXA group which had 58 patients and (2) no TXA control group which had 137 patients. In the TXA group, 1 g IV TXA was administered 30 minutes before incision, and 1 g IA TXA was administered intraoperatively after fascia closure. No drains were placed, and soft spica was applied to the hip.
ISSN: 2090-3464
DOI: 10.1155/2020/9130462
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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