Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/5441
Title: Comorbidity within mental disorders: a comprehensive analysis based on 145 990 survey respondents from 27 countries
Authors: McGrath, J J
Lim, C C W
Plana-Ripoll, O
Holtz, Y
Agerbo, E
Momen, N C
Mortensen, P B
Pedersen, C B
Abdulmalik, J
Aguilar-Gaxiola, S
Al-Hamzawi, A
Alonso, J
Bromet, E J
Bruffaerts, R
Bunting, B
de Almeida, J M C
de Girolamo, G
De Vries, Y A
Florescu, S
Gureje, O
Haro, J M
Harris, M G
Hu, C
Karam, Elie
Kawakami, N
Kiejna, A
Kovess-Masfety, V
Lee, S
Mneimneh, Z
Navarro-Mateu, F
Orozco, R
Posada-Villa, J
Roest, A M
Saha, S
Scott, K M
Stagnaro, J C
Stein, D J
Torres, Y
Viana, M C
Ziv, Y
Kessler, R C
de Jonge, P
Affiliations: Faculty of Medicine 
Keywords: Cross-sectional study
Diagnosis and classification
Epidemiology
Population survey
Issue Date: 2020-01-12
Publisher: National Library of Medicine
Part of: Epidemiology and Psychiatric Sciences
Volume: 29
Abstract: 
Aims
Epidemiological studies indicate that individuals with one type of mental disorder have an increased risk of subsequently developing other types of mental disorders. This study aimed to undertake a comprehensive analysis of pair-wise lifetime comorbidity across a range of common mental disorders based on a diverse range of population-based surveys.

Methods
The WHO World Mental Health (WMH) surveys assessed 145 990 adult respondents from 27 countries. Based on retrospectively-reported age-of-onset for 24 DSM-IV mental disorders, associations were examined between all 548 logically possible temporally-ordered disorder pairs. Overall and time-dependent hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards models. Absolute risks were estimated using the product-limit method. Estimates were generated separately for men and women.

Results
Each prior lifetime mental disorder was associated with an increased risk of subsequent first onset of each other disorder. The median HR was 12.1 (mean = 14.4; range 5.2–110.8, interquartile range = 6.0–19.4). The HRs were most prominent between closely-related mental disorder types and in the first 1–2 years after the onset of the prior disorder. Although HRs declined with time since prior disorder, significantly elevated risk of subsequent comorbidity persisted for at least 15 years. Appreciable absolute risks of secondary disorders were found over time for many pairs.

Conclusions
Survey data from a range of sites confirms that comorbidity between mental disorders is common. Understanding the risks of temporally secondary disorders may help design practical programs for primary prevention of secondary disorders.
URI: https://scholarhub.balamand.edu.lb/handle/uob/5441
ISSN: 20457960
DOI: 10.1017/S2045796020000633
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

Show full item record

SCOPUSTM   
Citations

27
checked on Jul 2, 2022

Record view(s)

5
checked on Jul 2, 2022

Google ScholarTM

Check

Dimensions Altmetric

Dimensions Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.