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Title: Role of Kisspeptin-mediated signaling pathway in carcinogenesis and metastasis: Opposite sides of the same coin
Authors: Naureen, Humaira
Avnioglu, Seda
Yilmaz, Seher
Youssef, Lara 
Farooqi, Ammad Ahmad
Affiliations: Faculty of Medicine 
Keywords: Cancer
Issue Date: 2022-05-21
Publisher: Elsevier
Part of: A. Farooqi, M. Qureshi, U. Sabitaliyevi (Eds), Unraveling the Complexities of Metastasis : Transition from a Segmented View to a Conceptual Continuum. Elsevier.
Start page: 203
End page: 208
Discovery of Kisspeptin signaling has paradigmatically shifted our understanding about the instrumental role of transduction cascades in myriad of biological activities. Moreover, rapidly emerging evidence about central role of Kisspeptin signaling in carcinogenesis and metastasis has attracted wide-spread attention. However, kisspeptin-driven signaling has been shown to dualistically regulate carcinogenesis and metastasis. In this chapter, we have summarized recent refinements in our knowledge about diametrically opposite roles of kisspeptin-mediated signaling in metastasis. Together, this progress has expanded the list of downstream effectors of kisspeptin-driven signaling. Major outstanding questions in the field include how kisspeptin-driven signaling crosstalks with different signaling pathways to regulate carcinogenesis and metastasis.
ISBN: 9780128217894
DOI: 10.1016/B978-0-12-821789-4.00002-3
Type: Book Chapter
Appears in Collections:Faculty of Medicine

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