Role of Kisspeptin-mediated signaling pathway in carcinogenesis and metastasis: Opposite sides of the same coin

Abstract

Discovery of Kisspeptin signaling has paradigmatically shifted our understanding about the instrumental role of transduction cascades in myriad of biological activities. Moreover, rapidly emerging evidence about central role of Kisspeptin signaling in carcinogenesis and metastasis has attracted wide-spread attention. However, kisspeptin-driven signaling has been shown to dualistically regulate carcinogenesis and metastasis. In this chapter, we have summarized recent refinements in our knowledge about diametrically opposite roles of kisspeptin-mediated signaling in metastasis. Together, this progress has expanded the list of downstream effectors of kisspeptin-driven signaling. Major outstanding questions in the field include how kisspeptin-driven signaling crosstalks with different signaling pathways to regulate carcinogenesis and metastasis.