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Title: Drug-Encapsulated Cyclodextrin Nanosponges
Authors: Tannous, Maria
Caldera, Fabrizio
Hoti, Gjylije
Dianzani, Umberto
Cavalli, Roberta
Trotta, Francesco
Affiliations: Department of Chemistry 
Keywords: Antibacterial
Gas delivery
Issue Date: 2021
Publisher: Springer
Part of: Supramolecules in Drug Discovery and Drug Delivery
Start page: 247
End page: 283
To date, a number of nanocarriers, either inorganic or organic, have been developed to improve the delivery and therapeutic efficacy of various drugs. Drug delivery systems have attempted to overcome the undesirable pharmacokinetic problems encountered. Among the various nanomaterials that have been designed as potential nanocarriers, cyclodextrin-based polymers are of particular interest in this review.Cyclodextrins (CD) are a class of cyclic glucopyranose oligomers, obtained from starch by enzymatic action, with a characteristic toroidal shape that forms a truncated cone-shaped lipophilic cavity. The main common native cyclodextrins are named α, β, and γ which comprise six, seven, and eight glucopyranose units, respectively. Cyclodextrins have the capability to include compounds whose size and polarity are compatible with those of their cavity.Cyclodextrin-based cross-linked polymers, often referred to as "cyclodextrin nanosponges" (CDNSs), attract great attention from researchers for solving major bioavailability problems such as inadequate solubility, poor dissolution rate, and limited stability of some agents, as well as increasing their effectiveness and decreasing unwanted side effects.Registered patents about this novel system in various fields, different pharmaceutical applications, and classes of drugs encapsulated by CDNSs are detailed. The features outlined make CDNSs a promising platform for the development of innovative and advanced delivery systems.
ISSN: 10643745
DOI: 10.1007/978-1-0716-0920-0_19
Ezproxy URL: Link to full text
Type: Book Chapter
Appears in Collections:Department of Chemistry

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