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Title: Pathophysiology, clinical findings, and management of Fox-Fordyce disease: A systematic review
Authors: Salloum, Antoine
Bouferraa, Youssef
Bazzi, Nagham
Bou Zerdan, Maroun
Abi Chebl, Joanna
Chu, Thomas
Bachour, Julien
Benedetto, Anthony
Affiliations: Faculty of Medicine 
Keywords: Fox-ForDyce
Fox-Fordyce disease
Apocrine military
Apocrine sweat glands
Pruritic papular eruptions
Issue Date: 2022
Publisher: Wiley Online Library
Part of: Journal of cosmetic dermatology
Fox-Fordyce (FFD), also known as apocrine military, is an uncommon chronic inflammation of the apocrine sweat glands. It is characterized by pruritic, papular eruptions in apocrine-gland-bearing regions. FFD was described a century ago, but the exact pathogenesis of the disease and the management are not well understood.

This paper provides a wide understanding of the pathophysiology, clinical findings, and management of Fox-Fordyce disease. Its aim is to help the physician to diagnose and manage this entity accordingly.

A research was done using PubMed database on 12 April 12, 2020, and in order to retrieve all case reports, case series, cohort studies, randomized, and nonrandomized clinical trials were included describing FFD among patients.

A total of 43 articles and 68 patients were included in the study. The majority of patients were young females. The disease was bilateral in 90%, affected the axillae and to a lesser extent the pubic and the periareolar areas and rarely the thoracic area, the abdominal area, and the face. FFD followed a relapsing and remitting course, and an evident improvement in disease course was noted after menopause.

The typical FFD patient is a post-pubertal female and pre-menopause, presenting with pruritic papules in apocrine-gland-bearing regions. FFD can be sporadic or occurs in family, and it can be asymptomatic in 1/(3–4) of patients and can be triggered by laser hair removal and hormonal changes. Further randomized clinical trials assessing different treatment of FFD are now warranted.
ISSN: 14732130
DOI: 10.1111/jocd.14135
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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