Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/5248
Title: When Should a Brain MRI Be Performed in Children with New-Onset Seizures? Results of a Large Prospective Trial
Authors: Hourani, R
Nasreddine, W
Dirani, M
Hmaimess, G
Sabbagh, S
El Tourjuman, O
Wazne, J
Toufaili, H
AlArab, N
El Dassouki, M
Beydoun, A
Affiliations: Faculty of Medicine 
Issue Date: 2021
Publisher: National Library of Medicine
Part of: American Journal of Neuroradiology
Volume: 42
Issue: 9
Start page: 1695
End page: 1701
Abstract: 
Background and purpose: There is a paucity of data regarding the incidence of structural brain lesions in children with new-onset unprovoked seizures. Our aim was to determine the frequencies and types of epileptogenic lesions detected on a dedicated epilepsy protocol MR imaging according to age group, the presence of developmental delay, and the number and types of seizures.

Materials and methods: Consecutive children between 6 months and 18 years of age with new-onset unprovoked seizures were included. The frequencies and types of epileptogenic lesions were determined and then stratified according to sex, age groups, the presence of developmental delay, and the number and types of seizures at presentation. Multivariate analysis was used to identify variables significantly associated with the presence of epileptogenic lesions.

Results: One thousand children were included. An epileptogenic lesion was identified in 26%, with malformations of cortical development being the most common lesion (32%), followed by hypoxic-ischemic injury (20%) and vascular etiologies (16%). Univariate analysis showed a significant increase in the frequency of epileptogenic lesions with decreasing age, the presence of developmental delay, and the number and types of seizures at presentation. The presence of developmental delay and seizure type at presentation remained significant in a multivariate analysis.

Conclusions: We documented a relatively high rate of epileptogenic lesions in children with new-onset seizures, with the presence of developmental delay and specific seizure types being associated with a higher likelihood of detecting an epileptogenic lesion on neuroimaging. This study fulfills the requirements of the study design recommended by the Practice Committee of the American Academy of Neurology, and we hope that our results will assist the relevant societies and committees in formulating neuroimaging guidelines for children with new-onset seizures.
URI: https://scholarhub.balamand.edu.lb/handle/uob/5248
ISSN: 01956108
DOI: 10.3174/ajnr.A7193
Type: Journal Article
Appears in Collections:Faculty of Medicine

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