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Title: Cancer chemopreventive role of fisetin: Regulation of cell signaling pathways in different cancers
Authors: Farooqi, Ahmad Ahmad
Naureen, Humaira
Zahid, Rabbia
Youssef, Lara 
Attar, Rukset
Xu, Baojun
Affiliations: Faculty of Medicine 
Keywords: Fisetin
Cancer prevention
Cell signaling pathway
Issue Date: 2021
Publisher: ScienceDirect
Part of: Pharmacological Research
Volume: 172
It is becoming progressively more understandable that pharmaceutical targeting of drug-resistant cancers is challenging because of intra- and inter-tumor heterogeneity. Interestingly, naturally derived bioactive compounds have unique ability to modulate wide-ranging deregulated oncogenic cell signaling pathways. In this review, we have focused on the available evidence related to regulation of PI3K/AKT/mTOR, Wnt/β-catenin, NF-κB and TRAIL/TRAIL-R by fisetin in different cancers. Fisetin has also been shown to inhibit the metastatic spread of cancer cells in tumor-bearing mice. We have also summarized how fisetin regulated autophagy in different cancers. In addition, this review also covers fisetin-mediated regulation of VEGF/VEGFR, EGFR, necroptosis and Hippo pathway. Fisetin has entered into clinical trials particularly in context of COVID19-associated inflammations. Furthermore, fisetin mediated effects are also being tested in clinical trials with reference to osteoarthritis and senescence. These developments will surely pave the way for full-fledge and well-designed clinical trials of fisetin in different cancers. However, we still have to comprehensively analyze and fully unlock pharmacological potential of fisetin against different oncogenic signaling cascades and non-coding RNAs. Fisetin has remarkable potential as chemopreventive agent and future studies must converge on the identification of additional regulatory roles of fisetin for inhibition and prevention of cancers.
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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