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Title: Synthesis and characterization of a novel amphiphilic block copolymer
Authors: Mhanna, Georgia
Advisors: Nakat, Hanna El 
Subjects: Drug delivery systems
Block Copolymers
Issue Date: 2013
This thesis presents the synthesis procedure of the novel amphiphilic block copolymer poly(ethylene glycol)-b-poly(lactic acid) (PEG-b-PLA) and its various characterization techniques in order to explore the applicability of this copolymer as an agent of encapsulation for hydrophobic drugs. The synthesis consists of ring-opening polymerization (ROP) of L-lactide with stannous octoate (Sn(Oct)2) as a catalyst and poly(ethylene glycol) methyl ether (mPEG) as an initiator. The copolymer is characterized and confirmed by 1H-NMR spectroscopy, Gel Permeation Chromatography (GPC), and Fourier Transform Infrared spectroscopy (FTIR). The thermal properties of the synthesized copolymer are determined by Differential Scanning Calorimeter (DSC). The nanoscale size (100-130 nm) and its distribution is verified by Dynamic Light Scattering (DLS) and the critical micelle concentration (CMC) is determined by fluorescence spectrophotometry. The UV measurements show that the polymer has a high encapsulation efficiency (72%) and is able to enhance (28 times) the solubility of a hydrophobic drug, namely Ibuprofen, in an aqueous medium. The results of this study reveal that the novel copolymer could be a potential candidate for hydrophobic drug delivery systems.
Includes bibliographical references (p.42-45).

Supervised by Dr. Hanna El Nakat.
Rights: This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the personal and educational use exceptions must be obtained from the copyright holder
Ezproxy URL: Link to full text
Type: Thesis
Appears in Collections:UOB Theses and Projects

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