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Title: The effect of aldosterone on glucose absorption in the jejunum of adult colectomized rats
Authors: Deeba, Elie
Advisors: Khachab, Maha 
Subjects: Glucose
Intestinal absorption
Issue Date: 2014
The colon is the major site for water and electrolyte absorption. Previous work in our lab has shown that total colectomy alters the absorptive function of the small intestine for glucose. The purpose of the present study is to investigate whether a possible hormonal mechanism is responsible for the absorptive alterations of glucose that occur in the jejunum post-colectomy. Aldosterone was inhibited using spironolactone injections for a period of 15 days, during which, food and water intakes and feces consistency were documented. Glucose absorption was also measured using in-vivo single pass perfusion at day 15. Results have revealed a significant decrease in glucose absorption upon inhibition of aldosterone 15 days post-colectomy. A failure to regain weight loss, an increase in water intake, and no change in food intake were observed in aldosterone inhibited rat models. These results suggest a significant role for aldosterone in maintaining glucose and water absorption post-colectomy.
Includes bibliographical references (p.43-51).

Supervised by Dr. Maha Khachab.
Rights: This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the personal and educational use exceptions must be obtained from the copyright holder
Ezproxy URL: Link to full text
Type: Thesis
Appears in Collections:UOB Theses and Projects

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