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Title: CXCL5 rs352046 polymorphism association with non small cell lung carcinoma prevalence and stages among two Lebanese medical centers
Authors: Nicolas, Adele
Advisors: Muallem, Hind
Subjects: Inflammation
Carcinoma, Non-Small--Cell Lung diagnosis
Single nucleotide polymorphisms
Issue Date: 2016
Existing data links inflammation with two types of non-small cell lung carcinoma (NSCLC), adenocarcinoma (AD) and squamous cell carcinoma (SqCC). Tumor progression, angiogenesis and metastasis are highly influenced by higher expression level of CXCL5 chemokine. rs352046 variant (-156 G>C) of CXCL5 gene is located at the promoter binding site for the transcription factors myeloid zinc finger (MZF 1-4) and proven to be related to significantly higher CXCL5 plasma concentration. The novelty of the study resided in examining the association of CXCL5 rs352046 single nucleotide polymorphism (SNP) with NSCLC prevalence and stages. A total of 60 NSCLC patients and 60 controls were recruited from two Lebanese hospitals for blood sample collection. TaqMan genotyping assay was performed to screen CXCL5 rs352046 SNP. The proportions of the GC and CC genotypes were 24.2% and 0.8% respectively among participants. The proportion of GC genotype was 26.7% among NSCLC patients. No significant difference in genotypes distribution was detected between NSCLC patient and control groups (P = 0.67). Interestingly, all NSCLC patients with GC genotype were in late stages: stage III (31.2%) and IV (68.8%). So Far, there was no significant association between the SNP and tumors stages (P = 0.26). Patients presented a significantly heavier smoking behavior compared to controls (1.9 packs/day, P = 0.04) and were more subjected to passive smoking (2.0 persons/house, P = 0.03). Only 10.2% of patients stopped smoking for 6 months before diagnosis, compared to 27.1% of controls (P = 0.03). No significant association was detected between alcohol consumption, chronic lung inflammatory disorders, reproductive history and NSCLC prevalence. Findings suggested that CXCL5 rs352046 was not associated with NSCLC prevalence. In addition, smoking is potentially associated with NSCLC prevalence like in other countries. A potential association of CXCL5 rs352046 SNP with NSCLC prognosis requires further longitudinal studies with a larger sample size.
Includes bibliographical references (p. 84-87).

Supervised by Dr. Hind Muallem.
Rights: This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the personal and educational use exceptions must be obtained from the copyright holder
Ezproxy URL: Link to full text
Type: Project
Appears in Collections:UOB Theses and Projects

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