Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/2717
Title: Vitamin D receptor gene polymorphisms modulate the skeletal response to vitamin D supplementation in healthy girls
Authors: Arabi, Asma
Zahed, Laila 
Mahfoud, Ziyad
Onsi, Lina El
Nabulsi, Mona
Maalouf, Joyce
Hajj Fuleihan , Ghada El
Affiliations: Faculty of Medicine 
Keywords: Bone health
Polymorphisms
Vitamin D receptor gene
Subjects: Adolescents
Vitamin D
Issue Date: 2009
Part of: Journal of bone
Volume: 45
Issue: 6
Start page: 1091
End page: 1097
Abstract: 
Objectives Vitamin D receptor (VDR) gene plays an important role in bone mass regulation. We have previously shown a beneficial effect of vitamin D supplementation on bone mass in girls. This study investigated whether the musculo-skeletal response to Vitamin D was modulated by polymorphisms in VDR gene. Design Randomized placebo-controlled trial. Methods 179 girls (10–17 years), were randomly assigned to placebo or Vitamin D3 for one year. VDR genotypes were determined in 167 girls using BsmI, TaqI and ApaI restriction enzymes. Bone mass at the spine, hip, forearm and total body, and lean mass were measured by DXA at baseline and at one year. Results After one year, VDR gene polymorphisms using Bsm1 and TaqI restriction enzymes were associated with percent changes in bone area, BMC and BMD at multiple skeletal sites in the Vitamin D3 group but not in the placebo group. The least increments were observed in the BB and tt genotypes. No similar effect was observed with ApaI enzyme. This relationship between VDR genotypes and changes in BMD and BMC remained significant after adjustment for puberty, changes in lean mass, height and bone area. Conclusion VDR gene polymorphisms influence the skeletal response to vitamin D supplementation in healthy adolescent girls.
URI: https://scholarhub.balamand.edu.lb/handle/uob/2717
DOI: 10.1016/j.bone.2009.07.074
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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