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Title: Surface modification of silicone intraocular implants To inhibit cell proliferation
Authors: Yammine, Paolo 
Pavon-Djavid, Graciela
Helary, Gerard
Migonney, Veronique
Affiliations: Department of Chemistry 
Issue Date: 2005
Part of: Biomacromolecules
Volume: 6
Issue: 5
Start page: 2630
End page: 2637
Photo-cross-linkable polymers bearing cinnamic, sulfonate, and carboxylate groups were synthesized by radical polymerization leading to randomly distributed copolymers. These polymers were used to coat silicone intraocular lenses in order to reduce posterior capsule opacification, also named "secondary cataract". We previously demonstrated that polymers containing both carboxylate and sulfonate groups inhibit cell proliferation, and formulations with the ratio R = COO-/(COO- + SO3-) equal to 0.64 provided the highest inhibitory effect. Ionic polymers with this formulation were synthesized to contain a monomer with pendant siloxane groups in order to get compatibility with the silicone matrix of the intraocular lenses. Anchorage of the ionic polymer at the surface of the silicone implant was achieved by a cycloaddition reaction of the photosensitive groups according to two options. These modified silicone surfaces grafted onto intraocular lenses were shown to inhibit cell proliferation to 60%.
Type: Journal Article
Appears in Collections:Department of Chemistry

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