Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/2603
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dc.contributor.authorNasr, Zeinaen_US
dc.contributor.authorDow, Lukas Een_US
dc.contributor.authorPaquet, Marileneen_US
dc.contributor.authorChu, Jenniferen_US
dc.contributor.authorRavindar , Konthamen_US
dc.contributor.authorSomaiah, Ragamen_US
dc.contributor.authorDeslongchamps, Pierreen_US
dc.contributor.authorPorco Jr, John Aen_US
dc.contributor.authorLowe, Scott Wen_US
dc.contributor.authorPelletier, Jerryen_US
dc.date.accessioned2020-12-23T09:16:33Z-
dc.date.available2020-12-23T09:16:33Z-
dc.date.issued2013-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/2603-
dc.description.abstractBackground Chemotherapy-induced hair loss (alopecia) (CIA) is one of the most feared side effects of chemotherapy among cancer patients. There is currently no pharmacological approach to minimize CIA, although one strategy that has been proposed involves protecting normal cells from chemotherapy by transiently inducing cell cycle arrest. Proof-of-concept for this approach, known as cyclotherapy, has been demonstrated in cell culture settings. Methods The eukaryotic initiation factor (eIF) 4E is a cap binding protein that stimulates ribosome recruitment to mRNA templates during the initiation phase of translation. Suppression of eIF4E is known to induce cell cycle arrest. Using a novel inducible and reversible transgenic mouse model that enables RNAi-mediated suppression of eIF4E in vivo, we assessed the consequences of temporal eIF4E suppression on CIA. Results Our results demonstrate that transient inhibition of eIF4E protects against cyclophosphamide-induced alopecia at the organismal level. At the cellular level, this protection is associated with an accumulation of cells in G1, reduced apoptotic indices, and was phenocopied using small molecule inhibitors targeting the process of translation initiation. Conclusions Our data provide a rationale for exploring suppression of translation initiation as an approach to prevent or minimize cyclophosphamide-induced alopecia.en_US
dc.language.isoengen_US
dc.subjectChemotherapy-induced alopeciaen_US
dc.subjecteIF4Een_US
dc.subjectEIF4Aen_US
dc.subjectTranslation initiationen_US
dc.subjectGenetic engineered mouse modelen_US
dc.subjectCyclophosphamideen_US
dc.titleSuppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopeciaen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1186/2050-6511-14-58-
dc.contributor.affiliationDepartment of Biologyen_US
dc.description.volume14en_US
dc.date.catalogued2017-11-03-
dc.description.statusPublisheden_US
dc.identifier.OlibID174707-
dc.identifier.openURLhttps://doi.org/10.1186/2050-6511-14-58en_US
dc.relation.ispartoftextBMC pharmacol toxicolen_US
dc.provenance.recordsourceOliben_US
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